Browsing Toxins By Category
Displaying toxin 1376 - 1400 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2864 | Naltrexone 16590-41-3 | C20H23NO4 341.401 g/mol |  |
| Naltrexone is a pure opiate antagonist and has little or no agonist activity. The mechanism of action of naltrexone in alcoholism is not understood; however, involveme...more Number of Targets: 7 |
| T3D2863 | Amprenavir 161814-49-9 | C25H35N3O6S 505.627 g/mol |  |
| Amprenavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. Number of Targets: 5 |
| T3D2862 | Tizanidine 51322-75-9 | C9H8ClN5S 253.711 g/mol |  |
| Tizanidine reduces spasticity by increasing presynaptic inhibition of motor neurons through agonist action at a2-adrenergic receptor sites. Number of Targets: 4 |
| T3D2861 | Daunorubicin 20830-81-3 | C27H29NO10 527.520 g/mol |  |
| Daunorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Daunorubicin forms complexes with DNA by intercalation between b...more Number of Targets: 7 |
| T3D2860 | Flurazepam 17617-23-1 | C21H23ClFN3O 387.878 g/mol |  |
| Benzodiazepines bind nonspecifically to bezodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity,...more Number of Targets: 21 |
| T3D2859 | Midazolam 59467-70-8 | C18H13ClFN3 325.767 g/mol |  |
| It is thought that the actions of benzodiazepines such as midazolam are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which is one o...more Number of Targets: 23 |
| T3D2858 | Thioridazine 50-52-2 | C21H26N2S2 370.575 g/mol |  |
| Thioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hy...more Number of Targets: 15 |
| T3D2857 | Galantamine 357-70-0 | C17H21NO3 287.354 g/mol |  |
| Galantamine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinest...more Number of Targets: 19 |
| T3D2856 | Sumatriptan 103628-46-2 | C14H21N3O2S 295.400 g/mol |  |
| The 5-HT1B and 5-HT1D receptors function as autoreceptors, which inhibit the firing of serotonin neurons and a reduction in the synthesis and release of serotonin upon...more Number of Targets: 14 |
| T3D2855 | Nafarelin 76932-56-4 | C66H83N17O13 1322.471 g/mol |  |
| Like GnRH, initial or intermittent administration of nafarelin stimulates release of the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) ...more Number of Targets: 2 |
| T3D2853 | Acamprosate 77337-76-9 | C5H11NO4S 181.210 g/mol |  |
| The mechanism of action of acamprosate in maintenance of alcohol abstinence is not completely understood. Chronic alcohol exposure is hypothesized to alter the normal ...more Number of Targets: 7 |
| T3D2852 | Trazodone 19794-93-5 | C19H22ClN5O 371.864 g/mol |  |
| Trazodone binds at 5-HT2 receptor, it acts as a serotonin agonist at high doses and a serotonin antagonist at low doses. Like fluoxetine, trazodone's antidepressant ac...more Number of Targets: 15 |
| T3D2851 | Magnesium Sulfate 7487-88-9 | MgO4S 120.368 g/mol |  |
| Magnesium is the second most plentiful cation of the intracellular fluids. It is essential for the activity of many enzyme systems and plays an important role with reg...more Number of Targets: 6 |
| T3D2850 | Pentazocine 359-83-1 | C19H27NO 285.424 g/mol |  |
| The preponderance of evidence suggests that pentazocine antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. Number of Targets: 4 |
| T3D2849 | Pteroyl-D-glutamic acid 1492-18-8 | C20H23N7O7 473.439 g/mol |  |
| As leucovorin is a derivative of folic acid, it can be used to increase levels of folic acid under conditions favoring folic acid inhibition (following treatment of fo...more Number of Targets: 1 |
| T3D2848 | Propoxyphene 469-62-5 | C22H29NO2 339.471 g/mol |  |
| Propoxyphene acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Propoxyphene primarily affects OP3 receptors, which ...more Number of Targets: 3 |
| T3D2847 | Nystatin 1400-61-9 | C47H75NO17 926.095 g/mol |  |
| Nystatin interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. This results in inhibition of ergosterol ...more Number of Targets: 0 |
| T3D2844 | Astemizole 68844-77-9 | C28H31FN4O 458.570 g/mol |  |
| Astemizole competes with histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of aste...more Number of Targets: 15 |
| T3D2842 | Clorazepate 23887-31-2 | C16H11ClN2O3 314.723 g/mol |  |
| Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity...more Number of Targets: 18 |
| T3D2841 | Nicotinic acid 59-67-6 | C6H5NO2 123.109 g/mol |  |
| Niacin binds to Nicotinate D-ribonucleotide phyrophsopate phosphoribosyltransferase, Nicotinic acid phosphoribosyltransferase, Nicotinate N-methyltransferase and the N...more Number of Targets: 4 |
| T3D2840 | Fluphenazine 69-23-8 | C22H26F3N3OS 437.522 g/mol |  |
| Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believ...more Number of Targets: 17 |
| T3D2839 | Paramethadione 115-67-3 | C7H11NO3 157.167 g/mol |  |
| Dione anticonvulsants such as paramethadione reduce T-type calcium currents in thalamic neurons (including thalamic relay neurons). This inhibits corticothalamic trans...more Number of Targets: 1 |
| T3D2838 | Rifabutin 72559-06-9 | C46H62N4O11 847.005 g/mol |  |
| Rifabutin acts via the inhibition of DNA-dependent RNA polymerase in gram-positive and some gram-negative bacteria, leading to a suppression of RNA synthesis and cell ...more Number of Targets: 2 |
| T3D2837 | Butorphanol 42408-82-2 | C21H29NO2 327.461 g/mol |  |
| The exact mechanism of action is unknown, but is believed to interact with an opiate receptor site in the CNS (probably in or associated with the limbic system). The o...more Number of Targets: 3 |
| T3D2836 | Cisapride 81098-60-4 | C23H29ClFN3O4 465.945 g/mol |  |
| Cisapride acts through the stimulation of the serotonin 5-HT4 receptors which increases acetylcholine release in the enteric nervous system (specifically the myenteric...more Number of Targets: 11 |