Browsing Toxins By Category
Displaying toxin 1601 - 1625 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0126 | Plutonium 7440-07-5 | Pu 244.000 g/mol |  |
| The alpha radiation plutonium emits does not penetrate the skin but can irradiate internal organs when plutonium is inhaled or ingested. Particularly at risk are the s...more Number of Targets: 1 |
| T3D1159 | Manganese citrate 5968-88-7 | C6H5MnO7 244.038 g/mol |  |
| Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particu...more Number of Targets: 5 |
| T3D4676 | Azacitidine 320-67-2 | C8H12N4O5 244.205 g/mol |  |
| Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine is thought to induce antineoplastic activity via two mec...more Number of Targets: 3 |
| T3D2866 | Flurbiprofen 5104-49-4 | C15H13FO2 244.261 g/mol |  |
| Similar to other NSAIAs, the anti-inflammatory effect of flurbiprofen occurs via reversible inhibition of cyclooxygenase (COX), the enzyme responsible for the conversi...more Number of Targets: 11 |
| T3D2690 | Biotin 58-85-5 | C10H16N2O3S 244.311 g/mol |  |
| Biotin is necessary for the proper functioning of enzymes that transport carboxyl units and fix carbon dioxide, and is required for various metabolic functions, includ...more Number of Targets: 10 |
| T3D1687 | 1,1'-Azobis(cyclohexanecarbonitrile) 2094-98-6 | C14H20N4 244.335 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 39 |
| T3D4895 | 4-Acetyl-6-tert-butyl-1,1-dimethylindane 13171-00-1 | C17H24O 244.372 g/mol |  |
| Not Available Number of Targets: 4 |
| T3D2225 | 2-(Chloroacetyl)dibenzofuran 13067-90-8 | C14H9ClO2 244.673 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2663 | Clodronate 10596-23-3 | CH4Cl2O6P2 244.892 g/mol |  |
| The bisphosphonate group binds strongly to the bone mineral, hydroxyapatite. This explains the specific pharmacological action of these compounds on mineralized tissue...more Number of Targets: 9 |
| T3D1327 | Lead fluoride 7783-46-2 | F2Pb 245.200 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 29 |
| T3D1005 | Pyrolan 87-47-8 | C13H15N3O2 245.277 g/mol |  |
| Pyrolan is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active sites of...more Number of Targets: 2 |
| T3D1595 | Tetraammine palladium(II) chloride 13815-17-3 | Cl2H12N4Pd 245.450 g/mol |  |
| Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, an...more Number of Targets: 6 |
| T3D0822 | Pimpinellin 131-12-4 | C13H10O5 246.216 g/mol |  |
| Pimpinellin acts as antagonist of proteins with GABA receptor activity (L579). The mechanism of action many furocoumarins is based on their ability to form photoadduct...more Number of Targets: 3 |
| T3D0843 | Isopimpinellin 482-27-9 | C13H10O5 246.216 g/mol |  |
| Isopimpinelin strongly inhibits insulin-stimulated lipogenesis. It induces hepatic GSTs and is potent inhibitor of cytochrome P450 1A1/1B1. Oral administration of isop...more Number of Targets: 3 |
| T3D3642 | Diallyl phthalate 131-17-9 | C14H14O4 246.259 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 5 |
| T3D1267 | Tin telluride 12040-02-7 | SnTe 246.300 g/mol |  |
| Inorganic and organic tin compounds are weak inhibitors of alcohol dehydrogenase. (A183) Number of Targets: 7 |
| T3D4750 | Busulfan 55-98-1 | C6H14O6S2 246.302 g/mol |  |
| Busulfan is an alkylating agent that contains 2 labile methanesulfonate groups attached to opposite ends of a 4-carbon alkyl chain. Once busulfan is hydrolyzed, the me...more Number of Targets: 2 |
| T3D1571 | Aluminum butylate 2269-22-9 | C12H27AlO3 246.323 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D2942 | Mepivacaine 96-88-8 | C15H22N2O 246.348 g/mol |  |
| Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing ...more Number of Targets: 1 |
| T3D0315 | Nitarsone 98-72-6 | C6H6AsNO5 247.037 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D2266 | 2-Bromodibenzofuran 86-76-0 | C12H7BrO 247.087 g/mol |  |
| As a strong lachrymator, one of the most probable protein targets is the TRPA1 ion channel that is expressed in sensory nerves (trigeminal nerve) of the eyes, nose, mo...more Number of Targets: 2 |
| T3D0859 | Linamarin 554-35-8 | C10H17NO6 247.245 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 50 |
| T3D2795 | Meperidine 57-42-1 | C15H21NO2 247.333 g/mol |  |
| Meperidine is primarily a kappa-opiate receptor agonist and also has local anesthetic effects. Meperidine has more affinity for the kappa-receptor than morphine. Opiat...more Number of Targets: 15 |
| T3D1756 | Strontium bromide 10476-81-0 | Br2Sr 247.430 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D1551 | Ethylaluminum sesquichloride 12075-68-2 | C6H15Al2Cl3 247.505 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |