Browsing Toxins By Category
Displaying toxin 951 - 975 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2952 | Gabapentin 60142-96-3 | C9H17NO2 171.237 g/mol |  |
| Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhanc...more Number of Targets: 7 |
| T3D1108 | Barium hydroxide 17194-00-2 | BaH2O2 171.342 g/mol |  |
| Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to...more Number of Targets: 21 |
| T3D1701 | 2,6-Dichlorobenzonitrile 1194-65-6 | C7H3Cl2N 172.011 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 42 |
| T3D2704 | Menadione 58-27-5 | C11H8O2 172.180 g/mol |  |
| Menadione (vitamin K3) is involved as a cofactor in the posttranslational gamma-carboxylation of glutamic acid residues of certain proteins in the body. These proteins...more Number of Targets: 24 |
| T3D4773 | Capric acid 334-48-5 | C10H20O2 172.265 g/mol |  |
| It has been demonstrated that octanoic (OA) and decanoic (DA) acids compromise the glycolytic pathway and citric acid cycle functioning, increase oxygen consumption in...more Number of Targets: 4 |
| T3D0370 | Cadmium carbonate 513-78-0 | CCdO3 172.420 g/mol |  |
| Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available met...more Number of Targets: 19 |
| T3D1839 | Sodium selenite 10102-18-8 | Na2O3Se 172.940 g/mol |  |
| Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration ...more Number of Targets: 0 |
| T3D1158 | Manganous acetate 638-38-0 | C4H6MnO4 173.026 g/mol |  |
| Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particu...more Number of Targets: 5 |
| T3D4944 | 1-Nitronaphthalene 86-57-7 | C10H7NO2 173.168 g/mol |  |
| 1-Nitronaphthalene and its reactive products specifically targets the airway epithelium. Its toxicity is synergized by prior long-term ozone exposure. 1-NN appears to ...more Number of Targets: 4 |
| T3D4196 | Alpha-keto-delta-guanidinovaleric acid 3715-10-4 | C6H11N3O3 173.170 g/mol |  |
| Uremic toxins such as alpha-keto-delta-guanidinoacetic acid are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels ...more Number of Targets: 3 |
| T3D3087 | Swainsonine 72741-87-8 | C8H15NO3 173.210 g/mol |  |
| Swainsonine inhibits the activity of glycoside hydrolases, especially N-linked glycosylation. Inhibition of Golgi mannosidase II and other alpha-mannosidases causes th...more Number of Targets: 10 |
| T3D3474 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 28289-54-5 | C12H15N 173.254 g/mol |  |
| MPTP itself is not toxic, and as a lipophilic compound can cross the blood-brain barrier. Once inside the brain, MPTP is metabolized into the toxic cation 1-methyl-4-p...more Number of Targets: 1 |
| T3D1627 | Vanadium oxytrichloride 7727-18-6 | Cl3OV 173.300 g/mol |  |
| Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cells' phagocytotic ability and viability. The pentavalent fo...more Number of Targets: 47 |
| T3D3787 | 6-Deisopropylatrazine 1007-28-9 | C5H8ClN5 173.604 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D1795 | Dibromomethane 74-95-3 | CH2Br2 173.835 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 0 |
| T3D4959 | Pyrophosphate 14000-31-8 | O7P2 173.946 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D1667 | 2,4-Toluene diisocyanate 584-84-9 | C9H6N2O2 174.156 g/mol |  |
| 2,4-Toluene diisocyanate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of ac...more Number of Targets: 51 |
| T3D1668 | 2,6-Toluene diisocyanate 91-08-7 | C9H6N2O2 174.156 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 40 |
| T3D4869 | Dimethyl adipate 627-93-0 | C8H14O4 174.194 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4289 | L-Arginine 74-79-3 | C6H14N4O2 174.201 g/mol |  |
| Many of supplemental L-arginine's activities, including its possible anti-atherogenic actions, may be accounted for by its role as the precursor to nitric oxide or NO....more Number of Targets: 9 |
| T3D2452 | (2S,4R,5S)-Muscarine 300-54-9 | C9H20NO2 174.260 g/mol |  |
| Muscarine is a competitive inhibitor. It mimics the action of the neurotransmitter acetylcholine at acetylcholine receptors. (L1011) Number of Targets: 8 |
| T3D1309 | Ethyldichloroarsine 598-14-1 | C2H5AsCl2 174.889 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 45 |
| T3D1812 | Bromine pentafluoride 7789-30-2 | BrF5 174.896 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D1401 | Cobalt(II) succinate 3267-76-3 | C4H4CoO4 175.005 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D4310 | N-Acetyl-L-aspartic acid 997-55-7 | C6H9NO5 175.139 g/mol |  |
| The primary proposed functions of N-acetylaspartic acid include: 1) A neuronal osmolyte that is involved in fluid balance in the brain; 2) a source of acetate for lipi...more Number of Targets: 0 |