Browsing Toxins By Category
Displaying toxin 1726 - 1750 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0345 | Mercury selenide 20601-83-6 | HgSe 279.550 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 50 |
| T3D1016 | Tiocarbazil 36756-79-3 | C16H25NOS 279.441 g/mol |  |
| Some thiocarbamates (EPTC, Molinate, Pebulate, and Cycloate) share a common mechanism of toxicity, i.e. the inhibition of acetylcholinesterase. An acetylcholinesterase...more Number of Targets: 2 |
| T3D1121 | Barium silicofluoride 17125-80-3 | BaF6Si 279.403 g/mol |  |
| Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to...more Number of Targets: 21 |
| T3D2993 | Doxepin 1668-19-5 | C19H21NO 279.376 g/mol |  |
| The mechanism of action of doxepin is not completely understood. It is thought that like amitriptyline, doxepin enhances the actions of norepinephrine and serotonin by...more Number of Targets: 23 |
| T3D0978 | Karbutilate 4849-32-5 | C14H21N3O3 279.335 g/mol |  |
| Karbutilate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active site...more Number of Targets: 2 |
| T3D1088 | (±)-Metalaxyl 57837-19-1 | C15H21NO4 279.332 g/mol |  |
| Binds to nAChRs in nervous systems. It also causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (T10, A590) Number of Targets: 17 |
| T3D1459 | Zinc arsenite 10326-24-6 | As2O4Zn 279.250 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 45 |
| T3D1268 | Tin(II) bromide 10031-24-0 | Br2Sn 278.520 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 13 |
| T3D4812 | Alpha-Linolenic Acid 463-40-1 | C18H30O2 278.430 g/mol |  |
| Alpha Linolenic Acid or ALA is considered an essential fatty acid because it is required for human health, but cannot be synthesized by humans. It is in fact a plant-...more Number of Targets: 12 |
| T3D0015 | Dibenzo[a,h]anthracene 53-70-3 | C22H14 278.347 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 7 |
| T3D0629 | Pentacene 135-48-8 | C22H14 278.347 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D0636 | Picene 213-46-7 | C22H14 278.347 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D0052 | Dibutyl phthalate 84-74-2 | C16H22O4 278.344 g/mol |  |
| The most characteristic effect of di-n-butyl phthalate is testicular atrophy. Di-n-butyl phthalate exposure causes both the release of iron from hemoglobin and/or tran...more Number of Targets: 25 |
| T3D3644 | Diisobutyl phthalate 84-69-5 | C16H22O4 278.344 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 5 |
| T3D3973 | Monoethylhexyl phthalic acid 4376-20-9 | C16H22O4 278.344 g/mol |  |
| Not Available Number of Targets: 7 |
| T3D3503 | Fenthion 55-38-9 | C10H15O3PS2 278.328 g/mol |  |
| Fenthion is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more Number of Targets: 13 |
| T3D4074 | Coriamyrtin 2571-86-0 | C15H18O5 278.300 g/mol |  |
| Coriamyrtin has inhibitory activity when modulating receptors of the central nervous system. In other words, coriamyrtin, as a picrotoxin-like sesquiterpene lactones f...more Number of Targets: 0 |
| T3D3626 | Diazolidinyl urea 78491-02-8 | C8H14N4O7 278.219 g/mol |  |
| Diazolidinyl urea is a formaldehyde releaser. It is likely that formaldehyde toxicity occurs when intracellular levels saturate formaldehyde dehydrogenase activity, al...more Number of Targets: 3 |
| T3D0324 | Lead chloride 7758-95-4 | Cl2Pb 278.100 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 29 |
| T3D1154 | Calcium permanganate 10118-76-0 | CaMn2O8 277.949 g/mol |  |
| Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particu...more Number of Targets: 5 |
| T3D0275 | Adamsite 578-94-9 | C12H9AsClN 277.581 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 45 |
| T3D2975 | Perhexiline 6621-47-2 | C19H35N 277.488 g/mol |  |
| Perhexiline binds to the mitochondrial enzyme carnitine palmitoyltransferase (CPT)-1 and CPT-2. It acts by shifting myocardial substrate utilisation from long chain fa...more Number of Targets: 4 |
| T3D2934 | Maprotiline 10262-69-8 | C20H23N 277.403 g/mol |  |
| Maprotiline exerts its antidepressant action by inhibition of presynaptic uptake of catecholamines, thereby increasing their concentration at the synaptic clefts of th...more Number of Targets: 17 |
| T3D2480 | Amitriptyline 50-48-6 | C20H23N 277.403 g/mol |  |
| Amitriptyline is metabolized to nortriptyline which inhibits the reuptake of norepinephrine and serotonin almost equally. Amitriptyline inhibits the membrane pump mech...more Number of Targets: 44 |
| T3D2736 | Venlafaxine 93413-69-5 | C17H27NO2 277.402 g/mol |  |
| The exact mechanism of action of venlafaxine is unknown, but appears to be associated with the its potentiation of neurotrasmitter activity in the CNS. Venlafaxine and...more Number of Targets: 19 |