Browsing Toxins By Category
Displaying toxin 1376 - 1400 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2897 | Biperiden 514-65-8 | C21H29NO 311.461 g/mol |  |
| Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of...more Number of Targets: 5 |
| T3D3836 | Fenamidone 161326-34-7 | C17H17N3OS 311.401 g/mol |  |
| Not Available Number of Targets: 15 |
| T3D4765 | Tolazamide 1156-19-0 | C14H21N3O3S 311.400 g/mol |  |
| Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the...more Number of Targets: 3 |
| T3D3687 | Lysergic acid hydroxyethylamide 3343-15-5 | C18H21N3O2 311.378 g/mol |  |
| Ergoline alkaloids tend to act as a group, producing complex and variable effects of partial agonism or antagonism at adrenergic, dopaminergic, and serotonergic recept...more Number of Targets: 9 |
| T3D3863 | Imazaquin 81335-37-7 | C17H17N3O3 311.335 g/mol |  |
| Not Available Number of Targets: 6 |
| T3D4040 | Domoic acid 14277-97-5 | C15H21NO6 311.330 g/mol |  |
| Domoic acid acts as a neurotoxin. It induces excitotoxicity by an integrative action on ionotropic glutamate receptors at both sides of the synapse for which it has hi...more Number of Targets: 1 |
| T3D1189 | Copper chromite 12053-18-8 | Cr2Cu2O5 311.081 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 11 |
| T3D1105 | Barium ferrite 11138-11-7 | B2BaF8 310.936 g/mol |  |
| Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to...more Number of Targets: 21 |
| T3D4557 | Desloratadine 100643-71-8 | C19H19ClN2 310.821 g/mol |  |
| Like other H1-blockers, Desloratadine competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscl...more Number of Targets: 3 |
| T3D4921 | Diflubenzuron 35367-38-5 | C14H9ClF2N2O2 310.683 g/mol |  |
| One of the metabolites of diflubenzuron, PCA, is a proximate carcinogen. It is conjugated to form the carcinogen that can ionize and reat with DNA to form adducts whic...more Number of Targets: 2 |
| T3D4791 | Mestranol 72-33-3 | C21H26O2 310.430 g/mol |  |
| Mestranol is the 3-methyl ether of ethinylestradiol. Ethinylestradiol, is a synthetic derivative of estradiol. Ethinylestradiol is orally bio-active and the estrogen u...more Number of Targets: 6 |
| T3D1170 | Uranyl fluoride 13536-84-0 | F2H2O2U 310.040 g/mol |  |
| Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and prot...more Number of Targets: 1 |
| T3D2755 | Metixene 4969-02-2 | C20H23NS 309.468 g/mol |  |
| Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of...more Number of Targets: 5 |
| T3D2676 | Methadone 76-99-3 | C21H27NO 309.445 g/mol |  |
| Methadone is a mu-agonist; a synthetic opioid analgesic with multiple actions qualitatively similar to those of morphine, the most prominent of which involves the cent...more Number of Targets: 10 |
| T3D1730 | Gallium(III) bromide 13450-88-9 | Br3Ga 309.435 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D1339 | Methyltriethyl lead 1762-28-3 | C7H18Pb 309.400 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 29 |
| T3D2802 | Fluoxetine 54910-89-3 | C17H18F3NO 309.326 g/mol |  |
| Fluoxetine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholineste...more Number of Targets: 18 |
| T3D0131 | Amosite asbestos 12172-73-5 | (Na, K)0-1(Fe2+, Mg)2(Fe2+, Mg)5Si8O22(OH)2, approx. Fe2+5Mg2 Not Available |  |
| When asbestos fibers are inhaled, many are deposited on the epithelial surface of the respiratory tree. Fibers that are retained in the lung or mesothelium for long pe...more Number of Targets: 1 |
| T3D4200 | Inodxyl glucuronide 35804-66-1 | C14H15NO7 309.271 g/mol |  |
| Uremic toxins such as indoxyl-beta-D-glucuronide are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic t...more Number of Targets: 3 |
| T3D1540 | Strontium aluminate 12004-37-4 | Al2O5Sr2 309.200 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D2777 | Alprazolam 28981-97-7 | C17H13ClN4 308.765 g/mol |  |
| Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects muscle relaxation, anticonvulsant activity, motor ...more Number of Targets: 23 |
| T3D4586 | Pinazepam 52463-83-9 | C18H13ClN2O 308.762 g/mol |  |
| Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity...more Number of Targets: 18 |
| T3D3703 | 15-Deacetylcalonectrin 38818-66-5 | C17H24O5 308.370 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D0980 | Mecarbinzid 27386-64-7 | C13H16N4O3S 308.356 g/mol |  |
| Mecarbinzid targets beta tubulin in actively dividing cells. It binds to microtubules, interfering with cell functions, such as meiosis and intracellular transportatio...more Number of Targets: 1 |
| T3D2567 | Warfarin 81-81-2 | C19H16O4 308.328 g/mol |  |
| Warfarin inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of gluta...more Number of Targets: 10 |