Browsing Toxins By Category
Displaying toxin 2726 - 2750 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D1701 | 2,6-Dichlorobenzonitrile 1194-65-6 | C7H3Cl2N 172.011 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 42 |
| T3D1108 | Barium hydroxide 17194-00-2 | BaH2O2 171.342 g/mol |  |
| Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to...more Number of Targets: 21 |
| T3D2952 | Gabapentin 60142-96-3 | C9H17NO2 171.237 g/mol |  |
| Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhanc...more Number of Targets: 7 |
| T3D4703 | Metronidazole 443-48-1 | C6H9N3O3 171.154 g/mol |  |
| Metronidazole is a prodrug. Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form...more Number of Targets: 1 |
| T3D1776 | Benzyl bromide 100-39-0 | C7H7Br 171.034 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 1 |
| T3D0690 | Nickel tetracarbonyl 13463-39-3 | C4NiO4 170.734 g/mol |  |
| Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promot...more Number of Targets: 68 |
| T3D4193 | 4-Hydroxydecenal 73529-64-3 | C10H18O2 170.249 g/mol |  |
| Uremic toxins such as 4-Hydroxydecenal are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can ...more Number of Targets: 3 |
| T3D4712 | Propylthiouracil 51-52-5 | C7H10N2OS 170.232 g/mol |  |
| Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrog...more Number of Targets: 2 |
| T3D4631 | N-(2-Cyanoethyl)valine 51078-49-0 | C8H14N2O2 170.209 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 0 |
| T3D3019 | Levetiracetam 102767-28-2 | C8H14N2O2 170.209 g/mol |  |
| The precise mechanism(s) by which levetiracetam exerts its antiepileptic effect is unknown. The antiepileptic activity of levetiracetam was assessed in a number of ani...more Number of Targets: 5 |
| T3D4934 | Methyl beta-naphthyl ketone 93-08-3 | C12H10O 170.207 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D3949 | 4-Phenylphenol 92-69-3 | C12H10O 170.207 g/mol |  |
| Not Available Number of Targets: 8 |
| T3D3981 | 2-Biphenylol 90-43-7 | C12H10O 170.207 g/mol |  |
| Not Available Number of Targets: 5 |
| T3D3958 | Diethylthiophosphate 5871-17-0 | C4H11O3PS 170.167 g/mol |  |
| Diethylthiophosphate (DETP) induces DNA damage only in the hepatic cell lines, and this effect could be related to a secondary non-diffusible metabolite generated by t...more Number of Targets: 1 |
| T3D3738 | Penicillic acid 90-65-3 | C8H10O4 170.163 g/mol |  |
| Penicillic acid has been shown to inhibit alcohol and lactate dehydrogenases by forming covalent adducts with either cysteine or lysine residues at the enzyme active s...more Number of Targets: 9 |
| T3D1435 | Chromium(II) acetate 14976-80-8 | C4H6CrO4 170.084 g/mol |  |
| Trivalent chromium may also form complexes with peptides, proteins, and DNA, resulting in DNA-protein crosslinks, DNA strand breaks, DNA-DNA interstrand crosslinks, ch...more Number of Targets: 5 |
| T3D1830 | Carbon diselenide 506-80-9 | CSe2 169.930 g/mol |  |
| Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration ...more Number of Targets: 0 |
| T3D1297 | Arsenic pentafluoride 7784-36-3 | AsF5 169.914 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D1610 | Silver nitrate 7761-88-8 | AgNO3 169.873 g/mol |  |
| Metallic silver is oxidized and may deposit in the tissues, causing arygria. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, disr...more Number of Targets: 26 |
| T3D1123 | Barium sulfide 21109-95-5 | BaS 169.392 g/mol |  |
| Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to...more Number of Targets: 21 |
| T3D1120 | Barium peroxide 1304-29-6 | BaO2 169.326 g/mol |  |
| Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to...more Number of Targets: 21 |
| T3D4630 | 3-Aminobiphenyl 2243-47-2 | C12H11N 169.222 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4497 | Diphenylamine 122-39-4 | C12H11N 169.222 g/mol |  |
| Diphenylamine uncouples mitochondrial oxidative phosphorylation, resulting in a decrease in hepatocellular ATP content and consequently hepatocyte injury (A15350). Sho...more Number of Targets: 7 |
| T3D0232 | 4-Aminobiphenyl 92-67-1 | C12H11N 169.222 g/mol |  |
| 4-Aminobiphenyl requires metabolic activation in order to exert its toxicity. This is catalyzed by N-hydroxylation via cytochrome P450 1A2, then followed by O-sulfatio...more Number of Targets: 2 |
| T3D4154 | Norepinephrine 51-41-2 | C8H11NO3 169.178 g/mol |  |
| Uremic toxins such as noradrenalin are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stim...more Number of Targets: 19 |