Browsing Toxins By Category
Displaying toxin 1026 - 1050 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2911 | Nalbuphine 20594-83-6 | C21H27NO4 357.443 g/mol |  |
| Receptor studies show that nalbuphine exerts its action via binding to mu, kappa, and delta receptors, but not to sigma receptors. Nalbuphine is primarily a kappa agon...more Number of Targets: 3 |
| T3D2474 | Naftidrofuryl 31329-57-4 | C24H33NO3 383.524 g/mol |  |
| Naftidrofuryl blocks the type 2 serotonin (5-HT2) receptors and thereby inhibits the effects of serotonin-induced vasoconstriction
or platelet aggregation. It is also ...more Number of Targets: 3 |
| T3D2855 | Nafarelin 76932-56-4 | C66H83N17O13 1322.471 g/mol |  |
| Like GnRH, initial or intermittent administration of nafarelin stimulates release of the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) ...more Number of Targets: 2 |
| T3D4179 | N1-Methyl-4-pyridone-3-carboxamide 769-49-3 | C7H8N2O2 152.151 g/mol |  |
| Uremic toxins such as N-methyl-4-pyridone-3-carboxamide are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of u...more Number of Targets: 3 |
| T3D4178 | N1-Methyl-2-pyridone-5-carboxamide 701-44-0 | C7H8N2O2 152.151 g/mol |  |
| Uremic toxins such as N-methyl-2-pyridone-5-carboxamide are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of u...more Number of Targets: 3 |
| T3D3658 | n-Octyl n-decyl phthalate 119-07-3 | C26H42O4 418.609 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 0 |
| T3D0199 | N-Nitrosodimethylamine 62-75-9 | C2H6N2O 74.082 g/mol |  |
| The mechanism of NDMAinduced liver toxicity is not clearly understood but may be related to alkylation of cellular protein. (L1207) Number of Targets: 0 |
| T3D0112 | n-Nitrosodi-n-propylamine 621-64-7 | C6H14N2O 130.188 g/mol |  |
| Reactive metabolites of n-nitrosodi-n-propylamine are believed to form adducts with DNA, resulting in carcinogenic effects. (L216) Number of Targets: 1 |
| T3D3431 | N-Heptane 142-82-5 | C7H16 100.202 g/mol |  |
| Petroleum distillates are central nervous system depressants and cause pulmonary damage. (A600) Number of Targets: 0 |
| T3D4766 | N-Decane 124-18-5 | C10H22 142.282 g/mol |  |
| Not Available Number of Targets: 4 |
| T3D4810 | N-Butyl-Benzenesulfonamide 3622-84-2 | C10H15NO2S 213.297 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D1666 | n-Butyl isocyanate 111-36-4 | C5H9NO 99.131 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 39 |
| T3D3426 | n-Butane 106-97-8 | C4H10 58.122 g/mol |  |
| Butane is a simple asphyxiant and causes toxicity by displacing oxygen. It also affects the central nervous system by enhancing glycine receptors and inhibiting N-meth...more Number of Targets: 0 |
| T3D1789 | N-Bromosuccinimide 128-08-5 | C4H4BrNO2 177.984 g/mol |  |
| Organobromide compounds such as n-Bromosuccinimide are strong alkylating agents. Consequently they can readily modify free thiols (cysteines), methionines as well as ...more Number of Targets: 1 |
| T3D4310 | N-Acetyl-L-aspartic acid 997-55-7 | C6H9NO5 175.139 g/mol |  |
| The primary proposed functions of N-acetylaspartic acid include: 1) A neuronal osmolyte that is involved in fluid balance in the brain; 2) a source of acetate for lipi...more Number of Targets: 0 |
| T3D4631 | N-(2-Cyanoethyl)valine 51078-49-0 | C8H14N2O2 170.209 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 0 |
| T3D0252 | N,N-Dimethylformamide 1968-12-02 | C3H7NO 73.094 g/mol |  |
| While the mechanism of action of dimethyl formamide has not bee fully elucidated, thiocarbamate pesticides have been shown to inhibit aldehyde dehydrogenases. (A2459) Number of Targets: 4 |
| T3D4198 | N(6)-Carboxymethyllysine 5746-04-3 | C8H16N2O4 204.224 g/mol |  |
| Uremic toxins such as carboxymethyllysine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins c...more Number of Targets: 3 |
| T3D4215 | N'-nitrosonornicotine 16543-55-8 | C9H11N3O 177.203 g/mol |  |
| Not Available Number of Targets: 3 |
| T3D3114 | Myristicin 607-91-0 | C11H12O3 192.211 g/mol |  |
| Myristicin exerts possible neurotoxic effects on dopaminergic neurons and is a weak inhibitor of monoamine oxidase. (L1271) Number of Targets: 2 |
| T3D4599 | Myristic acid 544-63-8 | C14H28O2 228.371 g/mol |  |
| Not Available Number of Targets: 3 |
| T3D2584 | Myotoxin (Crotalus viridis viridis) 132821-30-8 | Not Available 4827.755 g/mol |  |
| Myotoxins work by a non-enzymatic mechanism that leads to severe muscle necrosis, causing paralysis and eventually death. They may also modify voltage-sensitive sodium...more Number of Targets: 14 |
| T3D2960 | Mycophenolic acid 24280-93-1 | C17H20O6 320.337 g/mol |  |
| Mycophenolic acid is a potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and therefore inhibits the de novo pa...more Number of Targets: 5 |
| T3D3889 | Myclobutanil 88671-89-0 | C15H17ClN4 288.775 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 19 |
| T3D2456 | Muscimol 18174-72-6 | C4H6N2O2 114.103 g/mol |  |
| Muscimol is a potent GABAA agonist, activating the receptor for the brain's major inhibitory neurotransmitter, GABA. Muscimol actually binds to the same binding site o...more Number of Targets: 11 |